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1. |
Article |
Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice. Nature Communications 15,pp.4531 (Collaboration) 2024/06 |
| Language | English | | Publication Date | 2024/06 | | Type | Research Paper | | Peer Review | With peer review | | Title | Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice. | | Contribution Type | Joint Work | | Journal | Nature Communications | | Journal Type | Another Country | | Volume, Issue, Pages | 15,pp.4531 | | Total page number | 11 | | International coauthorship | International coauthorship | | Author and coauthor | Myung Chung, Katsutoshi Imanaka, Ziyan Huang, Akiyuki Watarai, Mu-Yun Wang, Kentaro Tao, Hirotaka Ejima, Tomomi Aida, Guoping Feng & Teruhiro Okuyama | | Details | Individuals with autism spectrum disorder (ASD) have a higher prevalence of social memory impairment. A series of our previous studies revealed that hippocampal ventral CA1 (vCA1) neurons possess social memory engram and that the neurophysiological representation of social memory in the vCA1 neurons is disrupted in ASD-associated Shank3 knockout mice. However, whether the dysfunction of Shank3 in vCA1 causes the social memory impairment observed in ASD remains unclear. In this study, we found that vCA1-specific Shank3 conditional knockout (cKO) by the adeno-associated virus (AAV)- or specialized extracellular vesicle (EV)- mediated in vivo gene editing was sufficient to recapitulate the social memory impairment in male mice. Furthermore, the utilization of EV-mediated Shank3-cKO allowed us to quantitatively examine the role of Shank3 in social memory. Our results suggested that there is a certain threshold for the proportion of Shank3-cKO neurons required for social memory disruption. Thus, our study provides insight into the population coding of social memory in vCA1, as well as the pathological mechanisms underlying social memory impairment in ASD. | |
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2. |
Article |
Ventromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice. Nature Communications 14(1),pp.3458 (Collaboration) 2023 |
| Language | English | | Publication Date | 2023 | | Type | Research Paper (Scientific Journal) | | Peer Review | With peer review | | Title | Ventromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice. | | Contribution Type | Joint Work | | Journal | Nature Communications | | Journal Type | Another Country | | Volume, Issue, Pages | 14(1),pp.3458 | |
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3. |
Article |
Disrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice Molecular psychiatry 27(4),pp.2095-2105 (Collaboration) 2022 |
| Language | English | | Publication Date | 2022 | | Type | Research Paper (Scientific Journal) | | Peer Review | With peer review | | Title | Disrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice | | Contribution Type | Joint Work | | Journal | Molecular psychiatry | | Journal Type | Another Country | | Volume, Issue, Pages | 27(4),pp.2095-2105 | | Author and coauthor | K Tao, M Chung, A Watarai, Z Huang, MY Wang, T Okuyama | |
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4. |
Article |
Distinct functions of ventral CA1 and dorsal CA2 in social memory. Current opinion in neurobiology 68,pp.29-35 (Collaboration) 2021 |
| Language | English | | Publication Date | 2021 | | Type | Review Article or Commentary (Scientific Journal) | | Peer Review | With peer review | | Title | Distinct functions of ventral CA1 and dorsal CA2 in social memory. | | Contribution Type | Joint Work | | Journal | Current opinion in neurobiology | | Journal Type | Another Country | | Volume, Issue, Pages | 68,pp.29-35 | | Author and coauthor | A Watarai, K Tao, MY Wang, T Okuyama | |
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5. |
Article |
Diverse sensory cues for individual recognition. Development, Growth & Differentiation 62(9),pp.507 (Collaboration) 2020 |
| Language | English | | Publication Date | 2020 | | Type | Review Article or Commentary (Scientific Journal) | | Peer Review | With peer review | | Title | Diverse sensory cues for individual recognition. | | Contribution Type | Joint Work | | Journal | Development, Growth & Differentiation | | Journal Type | Another Country | | Volume, Issue, Pages | 62(9),pp.507 | | Author and coauthor | M Chung, MY Wang, Z Huang, T Okuyama | |
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6. |
Article |
Bumblebees express consistent, but flexible, speed-accuracy tactics under different levels of predation threat. Frontiers in Psychology 9,pp.368340 (Collaboration) 2018 |
| Language | English | | Publication Date | 2018 | | Type | Research Paper (Scientific Journal) | | Peer Review | With peer review | | Title | Bumblebees express consistent, but flexible, speed-accuracy tactics under different levels of predation threat. | | Contribution Type | Joint Work | | Journal | Frontiers in Psychology | | Journal Type | Another Country | | Volume, Issue, Pages | 9,pp.368340 | | Authorship | Lead author | | International coauthorship | International coauthorship | | Author and coauthor | MY Wang, L Chittka, TC Ings | |
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7. |
Article |
Individual recognition and the ‘face inversion effect’ in medaka fish (Oryzias latipes). eLife 6 (Collaboration) 2017 |
| Language | English | | Publication Date | 2017 | | Type | Research Paper (Scientific Journal) | | Peer Review | With peer review | | Title | Individual recognition and the ‘face inversion effect’ in medaka fish (Oryzias latipes). | | Contribution Type | Joint Work | | Journal | eLife | | Journal Type | Another Country | | Volume, Issue, Pages | 6 | | Authorship | Lead author,Corresponding author | | International coauthorship | International coauthorship | | Author and coauthor | MY Wang, H Takeuchi | |
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8. |
Article |
Sheep in wolf's clothing: multicomponent traits enhance the success of mimicry in spider-mimicking moths. Animal Behaviour 127,pp.219-224 (Collaboration) 2017 |
| Language | English | | Publication Date | 2017 | | Type | Research Paper (Scientific Journal) | | Peer Review | With peer review | | Title | Sheep in wolf's clothing: multicomponent traits enhance the success of mimicry in spider-mimicking moths. | | Contribution Type | Joint Work | | Journal | Animal Behaviour | | Journal Type | Another Country | | Volume, Issue, Pages | 127,pp.219-224 | | Authorship | Lead author,Corresponding author | | International coauthorship | International coauthorship | | Author and coauthor | MY Wang, V Vasas, L Chittka, SH Yen | |
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9. |
Article |
Speed–accuracy trade-offs and individually consistent decision making by individuals and dyads of zebrafish in a colour discrimination task. Animal Behaviour 103,pp.277-283 (Collaboration) 2015 |
| Language | English | | Publication Date | 2015 | | Type | Research Paper (Scientific Journal) | | Peer Review | With peer review | | Invitation | With invitation | | Title | Speed–accuracy trade-offs and individually consistent decision making by individuals and dyads of zebrafish in a colour discrimination task. | | Contribution Type | Joint Work | | Journal | Animal Behaviour | | Journal Type | Another Country | | Volume, Issue, Pages | 103,pp.277-283 | | Authorship | Lead author | | International coauthorship | International coauthorship | | Author and coauthor | MY Wang, CH Brennan, RF Lachlan, L Chittka | |
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10. |
Article |
Attention and individual behavioural variation in small-brained animals–using bumblebees and zebrafish as model systems. (Single) 2013 |
| Language | English | | Publication Date | 2013 | | Type | Doctoral Dissertation | | Peer Review | With peer review | | Title | Attention and individual behavioural variation in small-brained animals–using bumblebees and zebrafish as model systems. | | Contribution Type | Single Work | | Journal Type | Another Country | | Publisher | Queen Mary, University of London Press | |
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11. |
Article |
Can bees simultaneously engage in adaptive foraging behaviour and attend to cryptic predators? Animal Behaviour 86(4),pp.859-866 (Collaboration) 2013 |
| Language | English | | Publication Date | 2013 | | Type | Research Paper (Scientific Journal) | | Peer Review | With peer review | | Title | Can bees simultaneously engage in adaptive foraging behaviour and attend to cryptic predators? | | Contribution Type | Joint Work | | Journal | Animal Behaviour | | Journal Type | Another Country | | Volume, Issue, Pages | 86(4),pp.859-866 | | Authorship | Lead author | | International coauthorship | International coauthorship | | Author and coauthor | MY Wang, TC Ings, MJ Proulx, L Chittka | |
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12. |
Article |
Colour-independent shape recognition of cryptic predators by bumblebees. Behavioral Ecology and Sociobiology 66,pp.487-496 (Collaboration) 2012 |
| Language | English | | Publication Date | 2012 | | Type | Research Paper (Scientific Journal) | | Peer Review | With peer review | | Title | Colour-independent shape recognition of cryptic predators by bumblebees. | | Contribution Type | Joint Work | | Journal | Behavioral Ecology and Sociobiology | | Journal Type | Another Country | | Volume, Issue, Pages | 66,pp.487-496 | | Authorship | Lead author | | International coauthorship | International coauthorship | | Author and coauthor | TC Ings, MY Wang, L Chittka | |
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13. |
Article |
Exploring the jumping spider mimicry of Eugauria albidentata (Lepidoptera, Crambidae, Musotiminae) through ethological and visual ecological approaches. (Single) 2009 |
| Language | English | | Publication Date | 2009 | | Type | Masters Thesis | | Peer Review | With peer review | | Title | Exploring the jumping spider mimicry of Eugauria albidentata (Lepidoptera, Crambidae, Musotiminae) through ethological and visual ecological approaches. | | Contribution Type | Single Work | | Journal Type | Another Country | | Publisher | National Sun Yat-sen University Press | |
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