ICU Researchers Information System

（Last updated : 2021-04-16 06:03:46）

NUNOSHIBA, Tatsuo

Professor

Division of Arts and Sciences, College of Liberal Arts, International Christian University

■ Academic Background

1.	1983/04～1985/03	Graduate School, Division of Engineering, Doshisha University, Completed,
2.	1978/04～1983/03	Faculty of Engineering, Doshisha University, Graduated,

■ #Professional Background

1.	2009/09～	Professor, Division of Arts and Sciences, College of Liberal Arts, International Christian University
2.	2006/04～2012/03	an Expert on Genetic Toxicology, an Acting Chair in 4th Section of Pesticide Evaluation, Food Safety Commission of Japan, The Cabinet Office
3.	2001/04～2009/08	an associate professor, Graduate School of Life Sciences, Tohoku University
4.	1999/08～2001/03	an associate professor, Biological Institute, Graduate School of Sciences, Tohoku University
5.	1994/10～1999/07	an assistant professor, Biological Institute, Graduate School of Science, Tohoku Univeristy
6.	1991/05～1994/10	a postdoctoral fellow, Harvard School of Public Health
7.	1988/04～1991/03	a part-time lecturer, Doshisha University
8.	1987/04～1991/03	a part-time teacher, Doshisha Women's College of Liberal Arts.
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■ #Present Specialized Fields

Risk sciences of radiation and chemicals, Genetics/Chromosome dynamics, Science education, Molecular biology, Education for Environmental Studies, Education (Key Word：Science Education,Education for Environmental Studies,mutagenesis,carcinogenesis,non-genotoxic carcinogens,environmental mutagens,oxidative stress,stress response,gene,DNA replication,recombination,DNA repair,spontaneous mutagenesis)

■ #Books and Articles

1.	Article	Detection and analysis of UV-induced mutations in the chromosomal DNA of Arabidopsis Biochemical and Biophysical Research Communications 554(21),pp.89-93 (Collaboration) 2021/05
2.	Article	Development of a supF-based system for detection of mutations in the extreme thermophile Thermus thermophilus HB27. Mol Genet Genomics, 294, 1085-1093 (2019) 294,pp.1085-1093 (Collaboration) 2019/04
3.	Article	Cre/lox-based multiple markerless gene disruption in the genome of the extreme thermophile Thermus thermophilus. Mol Genet Genomics 293(1),pp.277-291 (Collaboration) 2018
4.	Article	Construction of a supF-based system for detection of mutations in the chromosomal DNA of Arabidopsis Molecular Genetics and Genomics 288,pp.707-715 (Collaboration) 2013
5.	Article	Effects of Oral Administration of Non-genotoxic Hepato-hypertrophic Compounds on Metabolic Potency of Rat Liver Gene and Environment 36,pp.1-9 (Collaboration) 2014
6.	Article	Challenge to Conquer Cancer ~New Trends in Mutation Research Genes and Environment 34,pp.55-57 (Collaboration) 2012
7.	Article	Effects of Ion Beam Radiation on Genome Integrity in Saccharomyces cerevisiae (Collaboration) 2012
8.	Article	Phenyl hydroquinone, Ames test-negative carcinogen, induces Hog1-dependent stress response signaling; implication for aneuploidy formation in Saccharomyces cerevisiae FEBS Journal 275,pp.5733-5744 (Collaboration) 2008/10
9.	Article	UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides DNA Repair 6,pp.1786-1793 (Collaboration) 2007/12
10.	Article	Ames test negative carcinogen, ortho-phenylphenol, binds tubulin and causes aneuploidy in buding yeast Mutation Res 617,pp.90-97 (Collaboration) 2007/04
11.	Article	Involvement of Y-family DNA polymerases in mutagenesis caused by oxidized nucleotides in Escherichia coli J Bacteriol 188,pp.4992-4995 (Collaboration) 2006/07
12.	Article	Spontaneous Mutagenesis in Escherichia coli and Saccharomyces cerevisiae Gene Environ 28,pp.9-15 (Collaboration) 2006/03
13.	Article	Spontaneous mutagenesis in haploid and diploid Saccharomyces cerevisiae Biochem Biophys Res Commun 325,pp.928-933 (Collaboration) 2004/12
14.	Article	A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae Nucleic Acids Res 32,pp.5339-5348 (Collaboration) 2004/10
15.	Article	Hydrogen peroxide-induced microsatellite instability in the Escherichia coli K-12 endogenous tonB gene Biochem Biophys Res Commun 306,pp.570-576 (Collaboration) 2003/06
16.	Article	Characterization of spontaneous mutation in the ∆soxR and SoxS overproducing strains of Escherichia coli J. Radiat. Res 43,pp.195-203 (Collaboration) 2002/06
17.	Article	Mutagenic target for hydroxyl radicals generated in Escherichia coli mutant deficient in Mu- and Fe-superoxide dismutases and Fur, a repressor for iron-uptake systems DNA Repair 1,pp.411-418 (Collaboration) 2002/05
18.	Article	Oxidative mutagenesis –Regulation of iron transporting systems and their role in protection from oxidative stress in Escherichia coli Gene Environ pp.147-158 (Single) 2002/05
19.	Article	Mechanisms for the oxidative stress response and oxidative mutagenesis in Escherichia coli Gene Environ pp.23-32 (Single) 2001/07
20.	Article	An in vivo approach to identifying sequence context of 8-oxoguanine mutagenesis Biochem Biophys Res Commun 284,pp.179-184 (Collaboration) 2001/06
21.	Article	Miscoding and misincorporation of 8-oxo-guanine during leading and lagging strand synthesis in Escherichia coli Mol Gen Genet 264,pp.836-841 (Collaboration) 2001/02
22.	Article	Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium Proc Natl Acad Sci U S A 97,pp.14257-14262 (Collaboration) 2000/12
23.	Article	Characterization of spontaneous mutation in the oxyR strain of Escherichia coli Biochem Biophys Res Commun 279,pp.427-432 (Collaboration) 2000/12
24.	Article	Role of iron and superoxide for generation of hydroxyl radical, oxidative DNA lesions, and mutagenesis in Escherichia coli J Biol Chem 274,pp.34832-34837 (Collaboration) 1999/12
25.	Article	Determination of the complete genomic DNA sequence of Thermoplasma volcanium GSS1 Proc Japan Acad 75,pp.213-218 (Collaboration) 1999/07
26.	Article	Role of glutathione on mutagenic and cytotoxic effects of acrolein in Escherichia coli Mutat Res 442,pp.1-8 (Collaboration) 1999/06
27.	Article	Cobaltous chloride-induced mutagenesis in the supF tRNA gene of Escherichia coli Mutagenesis 14,pp.249-253 (Collaboration) 1999/03
28.	Article	An improved system for selection of forward mutations in an Escherichia coli supF gene carried by plasmids J Rad Res 39,pp.263-270 (Collaboration) 1998/12
29.	Article	Two-stage gene regulation of the superoxide stress response soxRS system in Escherichia coli Critical Reviews in Eukaryotic Gene Expression 6,pp.377-389 (Single) 1996/12
30.	Article	Molecular genetics of the soxRS oxidative stress regulon of Escherichia coli: Molecular Microbiology Techniques PartA, Methods in Molecular Genetics (Collaboration) 1995/07
31.	Article	Roles of nitric oxide in inducible resistance of Escherichia coli to activated murine macrophages Infect and Immun 63,pp.794-798 (Collaboration) 1995/03
32.	Article	A cluster of constitutive mutations affecting the C-terminus of the redox-sensitive SoxR transcriptional activator Nucleic Acids Res 22,pp.2958-2962 (Collaboration) 1994/08
33.	Article	Specificity of the mutator caused by deletion of the yeast structural gene (APN1) for the major apurinic endonuclease Proc Natl Acad Sci USA 91,pp.8165-8169 (Collaboration) 1994/08
34.	Article	Activation by nitric oxide of an oxidative stress response that defends Escherichia coli against activated macrophages Proc Natl Acad Sci USA 90,pp.9993-9997 (Collaboration) 1993/11
35.	Article	Negative autoregulation by Escherichia coli SoxS protein: a dampening mechanism for the soxRS redox stress response J Bacteriol 175,pp.7492-7494 (Collaboration) 1993/11
36.	Article	Potent intracellular oxidative stress exerted by the carcinogenic 4-nitroquinoline-N-oxide Cancer Res 53,pp.3250-3252 (Collaboration) 1993/07
37.	Article	Two-stage control of an oxidative stress regulon: the Escherichia coli SoxR protein triggers redox-inducible expression of the soxS regulatory gene J Bacteriol 174,pp.6054-6060 (Collaboration) 1992/10
38.	Article	Cross adaptive response in Escherichia coli caused by pretreatment with H2O2 against formaldehyde and other aldehyde compounds Mutat Res 255,pp.265-271 (Collaboration) 1991/11
39.	Article	Protective effects of sodium selenite on killing and mutation by N-Methyl-N'-nitro- N-nitrosoguanidine in Escherichia coli Mutat Res 250,pp.73-77 (Collaboration) 1991/09
40.	Article	"Rec-lac test" for detecting SOS-inducing activity of environmental genotoxic substances Mutat Res 254,pp.71-77 (Collaboration) 1991/01
41.	Article	Genotoxicity of quinoxaline 1,4-dioxide derivatives in Escherichia coli and Salmonella typhimurium Mutat Res 217,pp.203-209 (Collaboration) 1989/05
42.	Article	Sodium arsenite inhibits spontaneous and induced mutations in Escherichia coli Mutation Research 184,pp.99-105 (Collaboration) 1987/09
43.	Article	Effect of pKM101 plasmid on lethal and mutagenic damage in UV-irradiated Escherichia coli strains Mutat Res 183,pp.39-44 (Collaboration) 1987/01
44.	Article	Protective effect of R-factor plasmid pKM101 on lethal damage by UV and chemical mutagens in E. coli strains with different DNA repairing capacities Mutat Res 141,pp.135-139 (Collaboration) 1984/11
45.	Other	Role of enzymes in antimutagenesis of human saliva and serum, In Antimutagenesis and Anticarcinogenesis Mechanisms, D.M. Shankel et al. Eds. (Collaboration) 1986/07
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■ #Academic Conference Presentation

1.	2015/11/28	Furuki wo Tazunete ~DNA damage and mutagenesis induced by oxidative stress (Japanese Environmental Mutagen Sciety 44th Annual Meeting Symposium1 "Biological Effects Induced by Oxidative Stress")
2.	2015/09/24	How does oxidative mutation come from?
3.	2008/12	Genetic Instability Inducers in Saccharomyces cerevisiae: Mutation in sanitizing enzymes for deaminated nucleotide lesions, Ham1, and a non-mutagenic carcinogen, phenyl hydroquinone (PHQ) (Symposium on ”DNA repair and genomic instability”)
4.	2007/05	Genome instability caused by endogenous nucleotide lesions and its prevention in Yeast (The 3rd Japan-US DNA Repair Meeting)
5.	2006/11	Sanitizing enzymes for nucleotide lesions in Saccharomyces cerevisiae and genomic instability (Workshop “Genomic Instability Induced by the Damaged Nucleotides and Its Repression”)
6.	2005/11	Inducers for chromosomal instability and the mechanisms (Symposium “Challenge against Carcinogenesis, a big Black Box”)
7.	2001/05	Oxidative mutagenesis— Regulation of iron transporting systems and their role on　 protection from oxidative stress in Escherichia coli — (Open symposium on　“Molecular Pathogenesis for Oxidative Stress”)
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■ #Lectures

1.	2010/12/12	“From Research Preferred University to Education Preferred Liberal Arts UniversityWhat do students expect? How can advisors respond? Which types of collaborations are needed? ”
2.	2009/12/10	Genomic Instability Inducers in Saccharomyces cerevisiae 　〜an Ames-negative carcinogen, Phenyl hydroquinone (PHQ)
3.	2009/11/14	Genetic Instability Inducers in Saccharomyces cerevisiae: Mutation in Cellular Defense System and Environmental Chemicals.
4.	2005/11	Identification of a novel Nudix hydrolase sanitizing oxidative nucleotide lesions in Saccharomyces cerevisiae
5.	2005/09	Genome Instability Caused by Endogenous Nucleotide Lesions
6.	2005/04	Regulation for oxidative stress defense functions
7.	2002/12	Isolation and identification of the functional homologue of E. coli MutT in Saccharomyces cerevisiae
8.	2002/10	Isolation and identification of the functional homologue of E. coli MutT in Saccharomyces cerevisiae
9.	2000/11	Mutagenesis induced by reactive oxygen species and the defense system,
10.	2000/06	Iron, oxygen, and spontaneous mutagenesis　-Implication of reactive oxygen species on spontaneous mutagenesis
11.	1998/11	Implication of iron in spontaneous mutagenesis in SOD deficient E. coli
12.	1998/07	Regulation of oxidative stress defense system
13.	1996/07	The new putative function regulated by E. coli superoxide response, soxRS: Stimutation of homologous recombination in E. coli constitutive mutant of SoxRS response
14.	1994/12	Oxidative mutagenesis and the defense system
15.	1994/10	Regulation of superoxide stress response SoxRS in Escherichia coli
16.	1994/05	Escherichia coli global response “SoxRS” and its regulation
17.	1994/05	Regulation of redox-stress response soxRS in Escherichia coli
18.	1993/10	E. coli stress response against superoxide
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■ #Academic Society Memberships

1.	2013/01～	Liberal and General Education Society of Japan
2.	2005～	Japanese Association of the Student Counseling
3.	2016～	Japanese Association of Environmental Education
4.	2012/07～	Japanese Society of Science Education
5.	2008～	Environmental Mutagen Society
6.	1995～2002	American Society of Microbology
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■ Educational Achievements

● Announcement concerning education
1.	2013	What Can Students Learn through the Project Based Active Learning that They Produce Scientific Event?

■ #Qualification and Licenses

2013/03

Certified Student Advisor "GAKUSEI SHIENSHI"（登録番号500001）

■ #Academic Awards

2016/05

Japanese Association of Student Counseling JASC

■ #Research Topics, Funded Research, and Grants-in-Aid for Scientific Research

1.	2005～	Study for methodology to learn social skills through science events cordination (Key Word : )
2.	2002～	Genomic instability induced by non-genotoxic carcinogens (Key Word : )
3.	1994～	Mechanisms for Stabilization of Genetic Information in Escherichia coli, Thermus thermophilus and Saccharomyces cerivisiae (Key Word : )

■ #E-Mail Addresses

■ #Grants-in-aid for Scientific Research Researcher Number

10270802