■ 著書・論文歴
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1. |
論文 |
Recent advances in methodologies of epigenomics Epigenomics pp.1-19 （共著） 2025/11 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2025/11 | | 形態種別 | 総説・解説（学術雑誌） | | 査読 | 査読あり | | 招待論文 | 招待あり | | 標題 | Recent advances in methodologies of epigenomics | | 執筆形態 | 共著 | | 掲載誌名 | Epigenomics | | 掲載区分 | 国外 | | 巻・号・頁 | pp.1-19 | | 担当区分 | 最終著者,責任著者 | | 著者・共著者 | Hiroaki Ohishi, Wan Kin Au Yeung | | 概要 | Rapid methodological breakthroughs over the past ten years have transformed epigenomics from bulk, population-averaged assays into single-cell, multi-omic, and intracellular spatial investigations. This review surveys the interconnected technology pillars that now map the epigenome with unprecedented breadth and resolution. First, advances in next-generation and long-read sequencing empower investigators to chart chromatin accessibility, histone and DNA modifications, and three-dimensional higher-order chromatin structure in thousands of individual cells while retaining allele-specific information across kilobase-long molecules. Second, live-cell fluorescence probes and multiplexed chromatin tracing enable visualizing the dynamic organization of epigenetic marks and genome architecture of intact nuclei and tissues. Third, integrative platforms merge base-level reads with their native 3D coordinates, providing a holistic view of gene regulation in physiologic context. We distill key biological insights yielded by each methodology, discuss unresolved and persistent limitations, and outline future directions toward routine, cost-effective investigations. Together, these innovations are redefining how we interrogate chromatin biology in health and disease. | | DOI | 10.1080/17501911.2025.2571391 | |
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論文 |
A deletion at the X-linked ARHGAP36 gene locus is associated with the orange coloration of tortoiseshell and calico cats Current Biology 35(12),pp.2816-2825 （共著） 2025/05 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2025/05 | | 形態種別 | 研究論文（学術雑誌） | | 査読 | 査読あり | | 標題 | A deletion at the X-linked ARHGAP36 gene locus is associated with the orange coloration of tortoiseshell and calico cats | | 執筆形態 | 共著 | | 掲載誌名 | Current Biology | | 掲載区分 | 国外 | | 巻・号・頁 | 35(12),pp.2816-2825 | | 担当区分 | 筆頭著者 | | 著者・共著者 | Hidehiro Toh, Wan Kin Au Yeung, Motoko Unoki, Yuki Matsumoto, Yuka Miki, Yumiko Matsumura, Yoshihiro Baba, Takashi Sado, Yasukazu Nakamura, Miho Matsuda, Hiroyuki Sasaki | | DOI | 10.1016/j.cub.2025.03.075 | | PMID | 40378840 | |
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論文 |
DPPA3 facilitates genome-wide DNA demethylation in mouse primordial germ cells BMC Genomics 25(1) （共著） 2024/04 |
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論文 |
The DNMT3A ADD domain is required for efficient de novo DNA methylation and maternal imprinting in mouse oocytes PLOS Genetics 19(8),pp.e1010855-e1010855 （共著） 2023/08 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2023/08 | | 形態種別 | 研究論文（学術雑誌） | | 査読 | 査読あり | | 標題 | The DNMT3A ADD domain is required for efficient de novo DNA methylation and maternal imprinting in mouse oocytes | | 執筆形態 | 共著 | | 掲載誌名 | PLOS Genetics | | 掲載区分 | 国外 | | 出版社・発行元 | Public Library of Science (PLoS) | | 巻・号・頁 | 19(8),pp.e1010855-e1010855 | | 著者・共著者 | Ryuji Uehara,Wan Kin Au Yeung,Keisuke Toriyama,Hiroaki Ohishi,Naoki Kubo,Hidehiro Toh,Isao Suetake,Kenjiro Shirane,Hiroyuki Sasaki | | DOI | 10.1371/journal.pgen.1010855 | | ISSN | /1553-7404 | | PermalinkURL | https://dx.plos.org/10.1371/journal.pgen.1010855 | |
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論文 |
Novel compound heterozygous mutations in UHRF1 are associated with atypical immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome with distinctive genome-wide DNA hypomethylation Human molecular genetics 32(9),pp.1439-1456 （共著） 2022/12 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2022/12 | | 形態種別 | 研究論文（学術雑誌） | | 査読 | 査読あり | | 標題 | Novel compound heterozygous mutations in UHRF1 are associated with atypical immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome with distinctive genome-wide DNA hypomethylation | | 執筆形態 | 共著 | | 掲載誌名 | Human molecular genetics | | 掲載区分 | 国外 | | 巻・号・頁 | 32(9),pp.1439-1456 | | 著者・共著者 | Motoko Unoki,Guillaume Velasco,Satomi Kori,Kyohei Arita,Yasukazu Daigaku,Wan Kin Au Yeung,Akihiro Fujimoto,Hirofumi Ohashi,Takeo Kubota,Kunio Miyake,Hiroyuki Sasaki | | DOI | 10.1093/hmg/ddac291 | | PMID | 36458887 | |
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論文 |
CMIC: predicting DNA methylation inheritance of CpG islands with embedding vectors of variable-length k-mers BMC bioinformatics 23(1),pp.371-371 （共著） 2022/09 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2022/09 | | 形態種別 | 研究論文（学術雑誌） | | 査読 | 査読あり | | 標題 | CMIC: predicting DNA methylation inheritance of CpG islands with embedding vectors of variable-length k-mers | | 執筆形態 | 共著 | | 掲載誌名 | BMC bioinformatics | | 掲載区分 | 国外 | | 巻・号・頁 | 23(1),pp.371-371 | | 担当区分 | 責任著者 | | 著者・共著者 | Osamu Maruyama,Yinuo Li,Hiroki Narita,Hidehiro Toh,Wan Kin Au Yeung,Hiroyuki Sasaki | | DOI | 10.1186/s12859-022-04916-3 | | PMID | 36096737 | |
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著書 |
Low Input Genome-Wide DNA Methylation Analysis with Minimal Library Amplification （共著） 2022/07 |
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8. |
論文 |
Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters Nature Cell Biology （共著） 2021/09 |
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論文 |
A convolutional neural network-based regression model to infer the epigenetic crosstalk responsible for CG methylation patterns BMC bioinformatics 22(1),pp.341-341 （共著） 2021/06 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2021/06 | | 形態種別 | 研究論文（学術雑誌） | | 査読 | 査読あり | | 標題 | A convolutional neural network-based regression model to infer the epigenetic crosstalk responsible for CG methylation patterns | | 執筆形態 | 共著 | | 掲載誌名 | BMC bioinformatics | | 掲載区分 | 国外 | | 巻・号・頁 | 22(1),pp.341-341 | | 担当区分 | 筆頭著者,責任著者 | | 著者・共著者 | Wan Kin Au Yeung,Osamu Maruyama,Hiroyuki Sasaki | | DOI | 10.1186/s12859-021-04272-8 | | PMID | 34162326 | |
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10. |
論文 |
Reprogramming of the histone H3.3 landscape in the early mouse embryo Nature structural & molecular biology 28(1),pp.38-49 （共著） 2021/01 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2021/01 | | 形態種別 | 研究論文（学術雑誌） | | 査読 | 査読あり | | 標題 | Reprogramming of the histone H3.3 landscape in the early mouse embryo | | 執筆形態 | 共著 | | 掲載誌名 | Nature structural & molecular biology | | 掲載区分 | 国外 | | 巻・号・頁 | 28(1),pp.38-49 | | 著者・共著者 | Takashi Ishiuchi,Shusaku Abe,Kimiko Inoue,Wan Kin Au Yeung,Yuka Miki,Atsuo Ogura,Hiroyuki Sasaki | | DOI | 10.1038/s41594-020-00521-1 | | PMID | 33169018 | |
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11. |
論文 |
A Rice Immunophilin Homolog, OsFKBP12, Is a Negative Regulator of Both Biotic and Abiotic Stress Responses International journal of molecular sciences 21(22) （共著） 2020/11 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2020/11 | | 形態種別 | 研究論文（学術雑誌） | | 査読 | 査読あり | | 標題 | A Rice Immunophilin Homolog, OsFKBP12, Is a Negative Regulator of Both Biotic and Abiotic Stress Responses | | 執筆形態 | 共著 | | 掲載誌名 | International journal of molecular sciences | | 掲載区分 | 国外 | | 巻・号・頁 | 21(22) | | 国際共著 | 国際共著 | | 著者・共著者 | Ming-Yan Cheung,Wan Kin Au Yeung,Kwan-Pok Li,Hon-Ming Lam | | DOI | 10.3390/ijms21228791 | | PMID | 33233855 | |
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12. |
論文 |
Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo Nature communications 11(1),pp.5417-5417 （共著） 2020/10 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2020/10 | | 形態種別 | 研究論文（学術雑誌） | | 査読 | 査読あり | | 標題 | Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo | | 執筆形態 | 共著 | | 掲載誌名 | Nature communications | | 掲載区分 | 国外 | | 巻・号・頁 | 11(1),pp.5417-5417 | | 国際共著 | 国際共著 | | 著者・共著者 | Julien Richard Albert,Wan Kin Au Yeung,Keisuke Toriyama,Hisato Kobayashi,Ryutaro Hirasawa,Julie Brind'Amour,Aaron Bogutz,Hiroyuki Sasaki,Matthew Lorincz | | DOI | 10.1038/s41467-020-19279-7 | | PMID | 33110091 | |
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13. |
論文 |
Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos Molecular cell 77(4),pp.825-839 （共著） 2020/02 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2020/02 | | 形態種別 | 研究論文（学術雑誌） | | 査読 | 査読あり | | 標題 | Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos | | 執筆形態 | 共著 | | 掲載誌名 | Molecular cell | | 掲載区分 | 国外 | | 巻・号・頁 | 77(4),pp.825-839 | | 国際共著 | 国際共著 | | 著者・共著者 | Zhenhai Du,Hui Zheng,Yumiko K Kawamura,Ke Zhang,Johanna Gassler,Sean Powell,Qianhua Xu,Zili Lin,Kai Xu,Qian Zhou,Evgeniy A Ozonov,Nathalie Véron,Bo Huang,Lijia Li,Guang Yu,Ling Liu,Wan Kin Au Yeung,Peizhe Wang,Lei Chang,Qiujun Wang,Aibin He,Yujie Sun,Jie Na,Qingyuan Sun,Hiroyuki Sasaki,Kikuë Tachibana,Antoine H F M Peters,Wei Xie | | DOI | 10.1016/j.molcel.2019.11.011 | | PMID | 31837995 | |
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論文 |
Characterization of genetic-origin-dependent monoallelic expression in mouse embryonic stem cells Genes to cells : devoted to molecular & cellular mechanisms 25(1),pp.54-64 （共著） 2020/01 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2020/01 | | 形態種別 | 研究論文（学術雑誌） | | 査読 | 査読あり | | 標題 | Characterization of genetic-origin-dependent monoallelic expression in mouse embryonic stem cells | | 執筆形態 | 共著 | | 掲載誌名 | Genes to cells : devoted to molecular & cellular mechanisms | | 掲載区分 | 国外 | | 巻・号・頁 | 25(1),pp.54-64 | | 担当区分 | 筆頭著者 | | 著者・共著者 | Hiroaki Ohishi,Wan Kin Au Yeung,Motoko Unoki,Kenji Ichiyanagi,Kei Fukuda,Shoji Maenohara,Kenjiro Shirane,Hatsune Chiba,Takashi Sado,Hiroyuki Sasaki | | DOI | 10.1111/gtc.12736 | | PMID | 31733167 | |
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論文 |
Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection Cell reports 27(1),pp.282-293 （共著） 2019/04 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2019/04 | | 形態種別 | 研究論文（学術雑誌） | | 査読 | 査読あり | | 標題 | Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection | | 執筆形態 | 共著 | | 掲載誌名 | Cell reports | | 掲載区分 | 国外 | | 巻・号・頁 | 27(1),pp.282-293 | | 担当区分 | 筆頭著者 | | 国際共著 | 国際共著 | | 著者・共著者 | Wan Kin Au Yeung,Julie Brind'Amour,Yu Hatano,Kazuo Yamagata,Robert Feil,Matthew C Lorincz,Makoto Tachibana,Yoichi Shinkai,Hiroyuki Sasaki | | DOI | 10.1016/j.celrep.2019.03.002 | | PMID | 30943408 | |
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16. |
著書 |
Drought Stress and Tolerance in Soybean （共著） 2013/01 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2013/01 | | 形態種別 | 単行本（学術書） | | 査読 | 査読あり | | 標題 | Drought Stress and Tolerance in Soybean | | 執筆形態 | 共著 | | 掲載区分 | 国外 | | 出版社・発行元 | IntechOpen | | 国際共著 | 国際共著 | | 著者・共著者 | Yee Shan Ku,Wan Kin Au Yeung,Yuk Lin Yung,Man Wah Li,Chaoqing Wen,Xueyi Liu,Hon Ming Lam | | PermalinkURL | https://www.intechopen.com/chapters/40090 | |
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17. |
論文 |
The GCN2 homologue in Arabidopsis thaliana interacts with uncharged tRNA and uses Arabidopsis eIF2α molecules as direct substrates Plant biology (Stuttgart, Germany) 15(1),pp.13-8 （共著） 2013/01 |
| 言語種別 | 英語 | | 発行・発表の年月 | 2013/01 | | 形態種別 | 研究論文（学術雑誌） | | 査読 | 査読あり | | 標題 | The GCN2 homologue in Arabidopsis thaliana interacts with uncharged tRNA and uses Arabidopsis eIF2α molecules as direct substrates | | 執筆形態 | 共著 | | 掲載誌名 | Plant biology (Stuttgart, Germany) | | 掲載区分 | 国外 | | 巻・号・頁 | 15(1),pp.13-8 | | 著者・共著者 | M-W Li,Wan Kin Au Yeung,H-M Lam | | 概要 | Phosphorylation of eIF2α is an important strategy for living organisms to adapt to metabolic and physiological changes that are often associated with external stimuli. GCN2 is one of the well-studied eIF2α kinases in yeast and mammals, which is responsible for the survival of the organism under amino acid starvation. Despite the downstream reactions being quite divergent, AtGCN2 exhibits a high primary sequence similarity to its yeast and animal counterparts. In this study, we provide experimental evidence to show that AtGCN2 shares similar biochemical properties to the yeast and animal homologues. Our in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2α homologues in A. thaliana, thus providing essential information for further understanding the functions of plant general control non-repressible (GCN) homologues. | | DOI | 10.1111/j.1438-8677.2012.00606.x | | PMID | 22672016 | |
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